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Sildenafil can be a powerful and selective inhibitor of cGMP specific phosphodiesterase kind 5 (PDE5) from the corpus cavernosum, where PDE5 is to blame for degradation of cGMP. Sildenafil provides a peripheral site of action on erections. Sildenafil has no direct relaxant impact on isolated human corpus cavernosum but potently improves the relaxan